Methodology towards the Construction of Bicyclo[2.2.2]diazaoctane Cores and its Application Towards the Synthesis of Brevianamide B
نویسنده
چکیده
Page Outlined in this paper is a series of work done towards the construction of bicyclo[2.2.2]diazaoctane structures found in a several natural products. Detailed work is shown for a general method of creating these cores by a domino sequence to rapidly generate these cores with enantio-and diastereoselectivity. A similar sequence this outlined and displayed in the formal synthesis of brevianamide B. This synthesis makes use of a similar domino sequence, but a new source of facial selectivity is used.
منابع مشابه
Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids.
Over eight different families of natural products consisting of nearly 70 secondary metabolites that contain the bicyclo[2.2.2]diazaoctane ring system have been isolated from various Aspergillus, Penicillium, and Malbranchea species. Since 1968, these secondary metabolites have been the focus of numerous biogenetic, synthetic, taxonomic, and biological studies and, as such, have made a lasting ...
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